Paper accepted in eLife!

My paper on Lognormal firing rate distribution in motor networks has been accepted for publication in eLife. You can find the preprint here.

Abstract
When spinal circuits generate rhythmic movements it is important that the neuronal activity remains within stable bounds to avoid saturation and to preserve responsiveness. Here, we simultaneously record from hundreds of neurons in lumbar spinal circuits of turtles and establish the neuronal fraction that operates within either a ‘mean-driven’ or a ‘fluctuation-driven’ regime. Fluctuation-driven neurons have a ‘supralinear’ input-output curve, which enhances sensitivity, whereas the mean-driven regime reduces sensitivity. We fi nd a rich diversity of firing rates across the neuronal population as reflected in a lognormal distribution and demonstrate that half of the neurons spend at least 50% of the time in the ‘fluctuation-driven’ regime regardless of behavior. Because of the disparity in input-output properties for these two regimes, this fraction may reflect a fine trade-off between stability and sensitivity in order to maintain excitability across behaviors.

2017-08-18T06:24:03+00:00 October 31st, 2016|News|